The International Institute for Sustainability with Knotted Chiral Meta Matter (SKCM²) is funded by the Japanese Ministry of Education, Culture, Sports, Science and Technology’s (MEXT) World Premier International Research Center Initiative (WPI). Our team of researchers cross-pollinates mathematical knot theory and chirality knowledge across disciplines and scales with the goal of creating designable artificial knot-like particles that exhibit highly unusual and technologically useful properties, which will both deepen our understanding of nature as well as be allow for technological innovation to solve global problems, such as climate change.