Shang-Te Danny HSUResearch Fellow & Deputy Director,
Academia Sinica

Institute of Biological Chemistry, Academia Sinica, Research Fellow & Deputy Director

sthsu_at_gate.sinica.edu.tw

Shang-Te Danny Hsu is a structural biologist whose research elucidates how post-translational modifications (PTMs) control protein structure, dynamics, and function. By integrating high-resolution NMR spectroscopy, cryo-electron microscopy, and mass spectrometry with AI-assisted modeling, his laboratory dissects the molecular logic by which modifications such as glycosylation and ubiquitination regulate protein behavior. His team emphasizes the functional annotation of structure–activity relationships, developing innovative analytical and computational workflows to quantify conformational and compositional heterogeneity in complex protein systems. Their multidisciplinary approach bridges chemistry, structural biology, and data science, establishing new frameworks for understanding how PTMs orchestrate cellular communication and proteostasis. Through this work, Dr. Hsu aims to uncover fundamental principles of molecular regulation that inform the design of next-generation therapeutic strategies.

Danny's Website

Media Coverage & Related Links
Open Access Release: ‘Allosteric network of dynamic coupling within BAP1-UCH revealed by methyl NMR’ in Nature Communications
Understanding Knotted Proteins: From Birth to Degradation
WPI-PI Shang-Te Danny Hsu Awarded 2024 Franco-Taiwanese Grand Scientific Prize by National Science and Technology Council of Taiwan and the French Academy of Sciences