Prasanna S. Ghalsasi (The M. S. University of Baroda) Transferring to Triggering of Chirality: A Novel Synthetic Roadmap
One of the common strategies to design chiral materials is to implant accessible chiral organic molecules. But future materials, especially with non-linear behaviour, are not shown by these addenda-chirality from the molecule. That means to observe structural and functional chirality need of new synthetic methodologies, akin to asymmetric synthesis followed in organic chemistry.
I will first review my initial efforts on chiral molecule driven molecular magnets with possible Multiferroic behaviour. This include, synthetic strategy for a set of Organic-inorganic hybrids having distorted perovskite type structure. Key features are- (a) environmentally benign routes at gas-solid and liquid-solid interface, (b) bending of super-exchange pathway using high pressure; and (c) conglomerate crystallization of A2CuCl4 compounds, where A is Chiral organic ligand.
Curiosity driven experiments with undergraduate students revealed synchronized formation of two chiral structures one of organic compounds and the other of inorganic one in a one pot, ‘issho ni’ (共に, アベックJapanese meaning for together). These open ended attempts explicitly showcase triggering of chirality and not transferring of chirality, to the best of my knowledge first of its kind. This concept is discussed with the help of two preliminary attempts in this direction-(a) in-situ formation of axially chiral 1,1′ bi-2-naphthol (BINOL) along with silver nanoparticles; (b) formation of crystalline organic nitrate salts along with (chiral phase of) Fe2O3. The results of the first set of experiments are driven by adhesion-cohesion interaction (first time report in literature for the synthetic activity) while the latter highlight soft-chemistry approach.
References:
1. Hemant Mande, or Ashok Kumar, Prasanna Ghalsasi Cryst. Growth Des. (2014 and 2016): Phys. Chem Chem. Phys (2015); Sci Rep (2016); RSC Adv. (2015); CrystEngComm (2010); Inorg Chem (2017).
2. K. Bhanderi, P. S. Ghalsasi and K. Inoue, Nonconventional driving force for selective oxidative C-C coupling reaction due to concurrent and curious formation of Ag0. Scientific Report, 2021, 11(1), 1-11; K. Bhanderi, and Prasanna S. Ghalsasi Microscopic cavity to Macroscopic surface for asymmetric synthesis. Indian Patent (granted) 2021, 362, 870.; P. Ghalsasi, P. S. Ghalsasi and A. Shah; Interference rings as a tool for observing optical handedness of chiral materials. Indian Patent (granted) 2022, 397, 376.; Prasanna Ghalsasi, C. Gonsalves, Fabrication technique to deposit silver thin film on the inner surface of a narrow capillary. Indian Patent (granted) 2022, 401, 323.